Developmental regulation of Foxp3 expression during ontogeny

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Developmental regulation of Foxp3 expression during ontogeny

Thymectomy of neonatal mice can result in the development of autoimmune pathology. It has been proposed that thymic output of regulatory T (T reg) cells is delayed during ontogeny and that the development of autoimmune disease in neonatally thymectomized mice is caused by the escape of self-reactive T cells before thymectomy without accompanying T reg cells. However, the kinetics of T reg cell ...

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Regulatory T cells play important roles in the control of autoimmunity and maintenance of transplantation tolerance. Foxp3, a member of the forkhead/winged-helix family of transcription factors, acts as the master regulator for regulatory T-cell (Treg) development and function. Mutation of the Foxp3 gene causes the scurfy phenotype in mouse and IPEX syndrome (immune dysfunction, polyendocrinopa...

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Major histocompatibility complex class II expression distinguishes two distinct B cell developmental pathways during ontogeny

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 2005

ISSN: 1540-9538,0022-1007

DOI: 10.1084/jem.20050784